P8 DEFICIENCY LEADS TO ELEVATED PANCREATIC BETA CELL MASS BUT DOES NOT CONTRIBUTE TO INSULIN RESISTANCE IN MICE FED WITH HIGH-FAT DIET.

p8 deficiency leads to elevated pancreatic beta cell mass but does not contribute to insulin resistance in mice fed with high-fat diet.

BACKGROUND:p8 was initially described as being overexpressed in acute pancreatitis and encoding a ubiquitous stress protein.Analysis of insulin sensitivity and glucose tolerance in p8-knockout and haplodeficient mice revealed counterintuitive results.Thus, we determined glycemic control of p8 in mice Carcass detection and consumption by facultative

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